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Scrotal Neurotoxin Therapy

SmoothSac™ — Scrotal Botox for a Smoother, More Relaxed Scrotum

A targeted neurotoxin treatment that relaxes the scrotal dartos muscle, reducing wrinkling and tightness for a smoother, more natural appearance. Quick in-office procedure, no downtime.

Medically reviewed by Dr. Joel Pash · Updated February 2026

About the Treatment

What Is Scrotox? How Scrotal Botox Improves Appearance

SmoothSac™ is a scrotal neurotoxin treatment — commonly known as "Scrotox" or "scrotal Botox" — that reduces scrotal wrinkling and tightness for a smoother, more relaxed appearance. By injecting botulinum toxin (Botox, Xeomin, or Dysport) into the dartos muscle — the smooth muscle layer beneath the scrotal skin — SmoothSac™ temporarily prevents the contraction reflex that causes the scrotum to tighten and wrinkle.

The result is a smoother scrotal surface, a more relaxed hang, and a visually fuller appearance — benefits that many men report significantly improve their confidence and comfort. SmoothSac™ also helps reduce excessive scrotal sweating (hyperhidrosis) by inhibiting sweat gland activity in the treated area. The quick 15–20 minute in-office procedure requires no general anesthesia and no downtime. SmoothSac™ is available at all 19+ Upsize™ clinic locations and can be performed alongside the Upsize™ filler procedure or Firm-X™ treatment.

At a Glance

SmoothSac™ Scrotal Botox Quick Facts

15–20Minute Procedure
3–4 moResults Duration
50-100Units Typical
$890-$1890Per Treatment

Why SmoothSac?

Benefits of Scrotal Neurotoxin Treatment

Smoother Appearance

Reduces excessive scrotal wrinkling by relaxing the dartos muscle, creating a cleaner, more aesthetically pleasing surface.

More Relaxed Hang

Prevents the retraction reflex that pulls the scrotum tight against the body, allowing a naturally lower, more relaxed position.

Reduced Sweating

Inhibits sweat gland activity in the scrotal area, reducing excessive scrotal sweating (hyperhidrosis) for improved comfort and hygiene.

Fuller Visual Appearance

A relaxed scrotum appears visually larger and fuller — enhancing overall genital aesthetics and confidence.

Pairs with Upsize™ & Firm-X™

Combine with the Upsize™ filler procedure and/or Firm-X™ neuromodulator for comprehensive genital enhancement in a single visit.

Quick & No Downtime

15–20 minute in-office treatment. No general anesthesia. Return to normal activities immediately — most patients get it done on their lunch break.

The Process

How Scrotal Botox Treatment Works

1

Consultation

A confidential evaluation with your physician to discuss goals, expectations, and whether SmoothSac™ is right for your situation.

2

Preparation

The scrotal area is cleansed and a topical numbing cream is applied. Your physician marks the optimal injection sites.

3

Scrotal Botox Injection

Botulinum toxin is precisely injected into the dartos muscle at multiple points using a fine needle. Typically 75–100 units. The process takes about 15–20 minutes.

4

Enjoy Results

Effects develop over 1–2 weeks. A smoother, more relaxed scrotum with reduced wrinkling, less sweating, and a fuller visual appearance. No recovery period.

Is It Right for You?

Who Is a Good Candidate for Scrotox?

✓ Good Candidates

Men bothered by excessive scrotal wrinkling or tightness

Men who experience scrotal retraction ("shrinkage") in cold or stressful conditions

Men with excessive scrotal sweating (hyperhidrosis)

Men seeking a fuller, more relaxed scrotal appearance

Men combining with Upsize™ or Firm-X™ for comprehensive enhancement

✗ May Not Be Candidates

Men actively trying to conceive (discuss with physician)

Men with neuromuscular disorders (e.g., myasthenia gravis)

Men with active infection in the scrotal area

Men with known allergy to botulinum toxin products

Men on blood thinners (discuss with physician first)

Not sure if you're a candidate? Schedule a free phone consultation — your physician will evaluate your specific situation.

Questions?

Scrotal Botox & Scrotox FAQ

Scrotox — also called scrotal Botox or scrotal neurotoxin therapy — is a cosmetic procedure where botulinum toxin (Botox, Xeomin, or Dysport) is injected into the scrotal skin. It relaxes the dartos and cremaster muscles, reducing wrinkling and allowing the scrotum to hang in a smoother, more relaxed position.
Botulinum toxin blocks the release of acetylcholine at the neuromuscular junction, temporarily preventing muscle contraction. When injected into the scrotal dartos muscle, it reduces the retraction reflex that causes tightening and wrinkling — resulting in a smoother appearance and more relaxed hang.
Most patients report minimal discomfort. A topical numbing cream is applied before the procedure. The injections themselves are quick — the entire treatment takes only 15–20 minutes. Most patients describe the sensation as a brief pinch.
SmoothSac™ uses the same FDA-approved neurotoxin products that have been safely used in facial aesthetics for decades. The scrotal application is considered off-label but is performed by experienced, board-certified physicians. In clinical practice, side effects are generally mild — minor swelling or bruising that resolves within days. The injection targets only the dartos muscle layer, not the testes themselves.
Botulinum toxin is injected into the muscle layer above the testes — not into the testes directly. While animal studies at very high doses have shown potential effects on spermatogenesis, clinical experience in humans at standard doses has not demonstrated significant fertility concerns. However, if you are actively trying to conceive, discuss this with your physician during consultation.
Yes. Many patients add SmoothSac™ as a complement to their Upsize™ filler procedure or Firm-X™ neuromodulator treatment for comprehensive genital aesthetic enhancement in a single visit. Your physician will advise on the optimal approach.
Effects typically develop over 1–2 weeks as the neurotoxin takes full effect. You may notice initial relaxation within the first few days, with full smoothing and hang visible by week 2.
Results typically last 3–4 months. Some patients report effects lasting up to 6 months. Repeat treatments are available, and some patients find that results last progressively longer with repeated sessions as the muscle weakens over time.
SmoothSac™ is priced at $890-$1890 per treatment (depending on quantity.). Financing is available through CareCredit, Cherry, and United Credit. Visit our pricing page or financing page for details.
SmoothSac™ is available at all + Upsize™ clinic locations nationwide. Visit our clinic finder to locate your nearest office, or call for a free phone consultation.

Pricing

How Much Does Scrotox Cost?

$890-$1890
Per SmoothSac™ treatment · Financing available
CareCredit Cherry United Credit
Combine with Upsize™ and/or Firm-X™ for comprehensive enhancement — ask about package pricing.
Explore Financing Options

Take the Next Step

Book Your SmoothSac™ Consultation

Speak confidentially with a physician about scrotal Botox and how SmoothSac™ can help you look and feel your best. Free consultation, no obligation.

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