Firm-X™ Penile Botox for Enhanced Erections

Firmer erections for up to six months from one 20-minute visit, with no pill to time. In a placebo-controlled trial of men whose ED pills weren't working, one injection improved erections for 65 percent of them. It can be added to a filler visit.

What Is Firm-X™? What the Research Shows

Firm-X™ is what's often called penis botox: botulinum toxin (Botox, Xeomin or Dysport) injected into the corpus cavernosum, the erectile tissue of the penis. It relaxes the smooth muscle there, so blood flows in more easily when you're aroused, and erections are firmer.

The evidence is strong. In two randomized, placebo-controlled trials, a single injection improved erections, and in the larger one the effect lasted up to six months.1, 2 The details are below.

Botulinum toxin is FDA-approved for other uses; using it for erectile dysfunction is off-label.

Firm-X™ Penile Botox Quick Facts

Visit

~20 min

The injection itself takes a couple of minutes.

Works

2 weeks

Most men notice a difference within two weeks.

Lasts

6 months

Up to six months, and it can be repeated.

Price

$1,890

Consultation and follow-up included.

Benefits of Penile Neuromodulator Treatment

Firmer erections without planning around a pill. One treatment lasts up to six months, so there's nothing to take beforehand and nothing to time, and in the trials it helped men whose pills alone weren't enough.1

Firm-X™ works on firmness and filler on size, so the two go together. They can be done at the same visit, and 20 to 30 percent of our filler patients add it. How filler works

How Penile Botox Treatment Works

  1. The phone consultation. An Upsize™ expert goes over your erections, your health and any medications you take, and books you at the clinic nearest you.
  2. The examination. The doctor reviews your history, confirms Firm-X™ is right for you and sets the dose.
  3. The injection. The doctor injects the medicine into the erectile tissue with a fine needle. It takes a couple of minutes, the whole visit about twenty, and you go straight back to your day.
  4. The next two weeks. The effect builds over the first two weeks, and you come back for a follow-up visit.

Firm-X™ is offered at all 31 Upsize™ clinics.

Firm-X™ vs. ED Pills & Other ED Treatments

Firm-X™ED pillsSelf-injectionsPenile implant
How it is givenOne injection at the clinicA pill before sexAn injection you give yourself before sexSurgery
How long it worksUp to six monthsHoursOne to three hoursPermanent
Planning around sexNoYesYesNo
RecoveryNoneNoneNoneWeeks
Wears off on its ownYesYesYesNo

What the Published Studies Found

Abdelrahman et al., 2022. 70 men whose ED hadn't responded to pills were given one injection of botulinum toxin or a salt-water placebo, and kept taking their pills. At six weeks, 65 percent of the treated men reported better erections and 53 percent could have an erection firm enough for penetration, against one man on placebo, with no complications reported.1

El-Shaer et al., 2021. A randomized, placebo-controlled trial of 176 men with erectile dysfunction caused by blood flow. The injection improved erection hardness and blood flow in the penis, and the effect lasted up to six months.2

Giuliano et al., 2022. 123 men for whom pills or injections weren't doing enough had botulinum toxin added to their treatment. For 41 percent of them the benefit lasted at least six months, and the only side effects were two cases of brief discomfort.3

Who Is a Good Candidate for Penile Botox?

Men with erectile dysfunction, including men whose pills haven't worked well enough, and men having filler who want firmer erections too. Men on blood thinners and men with severe ED can usually have it as well; the doctor confirms at your visit.

Risks and side effects

Common and short-lived: some men have mild soreness or bruising where the needle went in, which passes within a few days. Across the published studies, the most common side effect was mild, brief penile pain, in 1.5 to 6 percent of men, and no serious side effects elsewhere in the body were reported.4, 5

Less common, as with any injection into the erectile tissue: bleeding into the penis, which can be painful and take weeks to settle; scarring of the erectile tissue, which can cause a bend or a firm area; and infection.

Rare: a prolonged erection, reported once in the published studies,5 and the spread of the toxin's effect described in the FDA warning below.

Contraindications

The FDA labeling for botulinum toxin lists two reasons not to be treated:6

  • an allergy or sensitivity to any botulinum toxin product or its ingredients
  • an infection where the injection would go

It also advises care in men with a nerve or muscle disorder such as myasthenia gravis, Lambert-Eaton syndrome or ALS, who may be at greater risk from the toxin's effects.

Who should not have it
  • Men who want more size: Firm-X™ works on firmness, and filler adds girth.
  • Men who have had a botulinum toxin injection anywhere in the last four months, until they've discussed it with the doctor.6

An erection lasting more than four hours is a medical emergency. Go to an emergency department; waiting can permanently damage the erectile tissue.

Penile Botox & Neuromodulator FAQ

Does the injection hurt?

It's brief: the injection itself takes a couple of minutes. Some men have mild soreness or bruising where the needle went in, which passes within a few days.

Can I keep taking my ED pills?

Yes. In the placebo-controlled trial of men whose pills weren't working, they kept taking them alongside the injection. Firm-X™ isn't a reason to stop anything you've been prescribed; that's a conversation with the doctor who prescribed it.

Is it the same Botox used for wrinkles?

It's the same family of medicines (Botox, Xeomin or Dysport), placed in the erectile tissue instead of the face. The doctor sets the dose.

Does it make the penis bigger?

No. Firm-X™ works on firmness, not size. Filler adds girth, and the two can be done at the same visit. How filler works →

What happens when it wears off?

You can have it again, and a repeat treatment costs the same $1,890.

All questions

How Much Does Penile Botox Cost?

$1,890 per treatment, including the consultation and a follow-up visit, and a repeat treatment costs the same. Most offices offer 0% APR financing for 6 or 12 months. Financing · All prices

Representative examples: $3,990 financed at 17.00% APR over 36 monthly payments of $142, total of payments $5,121; the same $3,990 at 0% APR over 12 months is $332.50 a month; $5,990 at 17.00% APR over 36 months is $214 a month, total of payments $7,688. Subject to credit approval by the third-party lender; your amount financed, APR, term and payment may differ. Promotional 0% APR offers are available only to qualified applicants and only for the promotional period; if the balance is not paid in full by then, the lender's standard APR applies to the remaining balance. Financing is provided by the lender, not Upsize LLC. Full financing disclosures.

FDA Boxed Warning: Distant Spread of Toxin Effect

Every botulinum toxin product carries this warning from the FDA.6 The effect of the toxin can spread away from where it was injected. When that happens it can cause muscle weakness, blurred vision, drooping eyelids, trouble swallowing, trouble speaking, and trouble breathing. Swallowing and breathing problems can be life threatening, and deaths have been reported. Symptoms have shown up anywhere from hours to weeks after an injection. Get emergency help straight away if you have any trouble swallowing, speaking or breathing after treatment.

Tell your doctor before treatment if you have a nerve or muscle disorder such as myasthenia gravis, Lambert-Eaton syndrome or ALS, if you have had any swallowing or breathing problem, or if you have had any botulinum toxin injection in the last four months.

Sources

  1. Abdelrahman IFS, Raheem AA, Elkhiat Y, Aburahma AA, Abdel-Raheem T, Ghanem H. Safety and efficacy of botulinum neurotoxin in the treatment of erectile dysfunction refractory to phosphodiesterase inhibitors: results of a randomized controlled trial. Andrology. 2022;10(2):254-261. PubMed
  2. El-Shaer W, Ghanem H, Diab T, Abo-Taleb A, Kandeel W. Intra-cavernous injection of BOTOX® […] for treatment of vasculogenic erectile dysfunction: randomized controlled trial. Andrology. 2021;9(4):1166-1175. PubMed
  3. Giuliano F, Joussain C, Denys P. Long-term effectiveness and safety of intracavernosal botulinum toxin A as an add-on therapy to phosphodiesterase type 5 inhibitors or prostaglandin E1 injections for erectile dysfunction. J Sex Med. 2022;19(1):83-89. PubMed
  4. Talavera Cobo V, Yanez Ruiz CA, Tapia Tapia MD, et al. Intracavernosal Botulinum Toxin Injection for Erectile Dysfunction: A Comprehensive Systematic Review. Life (Basel). 2025;15(12). PubMed
  5. Pang KH, et al. The effectiveness and safety of intracavernosal botulinum toxin injections in the management of erectile dysfunction: a systematic review and meta-analysis of clinical studies. Sex Med. 2025;13(2):qfaf034. PubMed
  6. U.S. Food and Drug Administration. BOTOX® (onabotulinumtoxinA) prescribing information, including the boxed warning and Medication Guide. FDA

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